Toxic Shock Syndrome
Lead investigators
Dr Shazia Adalat
Email: s.adalat@nhs.net
Tel: 0207 1884586
Dr Tom Dawson
Email: tom.dawson@nhs.net
Paediatric Nephrology Department
Evelina Children’s Hospital
Guys & St. Thomas’ NHS Trust
Westminster Bridge Road
London
SE1 7EH
Overview
- Toxic shock syndrome (TSS) is a rare toxin related disease with potentially fatal or catastrophic consequences.
- This aggressive disease is triggered by staphylococcal or streptococcal toxin release. Immune mediated superantigen responses to toxin result in sustained shock followed by multisystem illness. This may manifest as diarrhoea, thrombocytopenia, coagulopathy, renal failure, hepatic impairment, soft tissue necrosis or acute respiratory distress syndrome (ARDS).
- There is little data on the incidence of TSS in children in the UK or indeed significant case series commenting on presentation or outcome.
- This BPSU study will inform paediatricians about incidence and management of this potentially fatal condition
Duration: October 2008 – October 2009 (13 months)
Funding: Sir Peter Tizard Bursary, BPSU.
Ethical approval: This study has been approved by the Lewisham MREC (Ref: 08/H0810/16) and has been granted PIAG Section 251 Support (Ref: PIAG/BPSU 5-07 (FT2)/2008).
Further Information
- Protocol Card (PDF, 33KB, 2 pages)
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