BPSU - Neonatal Exchange Blood Transfusion (EBT) in Infants of 28 days of age or under in the United Kingdom and Republic of Ireland

Surveillance of neonatal exchange blood transfusion (EBT) commenced in October 2014. The study aims to ascertain the current incidence and complication rates of EBT, as well as the practical difficulties of performing an EBT.

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Lead investigator

Ruth Gottstein
Cental Manchester University Hospitals NHS Foundation Trust
Neonatal Intensive Care Unit
St Mary's Hospital,
Oxford Road
Manchester M13 9WL
 

Overview

Exchange Blood Transfusion (EBT) is now rare but remains an emergency treatment for very high or rapid rising serum bilirubin levels that are not responding to treatment with phototherapy. There is very little known about how often the procedure is performed currently in the UK & Ireland, or the complication rate. This information would be useful to inform medical practice and for counselling parents regarding consent for the procedure. 

The study aims to ascertain the current incidence and complication rates (including death) of EBT, as well as the practical difficulties of performing an EBT. There is insufficient understanding of the effect of current EBT procedures on the baby’s clotting and platelet count, and therefore uncertainty about when the baby should have additional blood component support. Systematic collection of routinely available laboratory data will enable better recommendations for future practice and neonatal exchange red cell component development. A better understanding of the current incidence of adverse metabolic outcomes as a result of EBT, morbidity and mortality will be invaluable to guide future practice.

Case definition: Any infant up to and including the age of 28 days undergoing an EBT during the past month.

Duration: October 2014 to October 2015 inclusive (13 months of surveillance)

Funding: NHS Blood and Transplant Trustees Fund Grant & NICU Endowment Fund, St. Mary’s Hospital, Manchester.

Ethical approval: This study has been approved by NRES Committee – North West – Greater Manchester Central (REC reference: 13/NW/0063; IRAS project ID: 115143) and has been granted Section 251 HRA-CAG permission (CAG Reference: 14/CAG/1010).

Further information

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Partners

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