BPSU - Reporting instructions

Download monthly reporting instructions for the British Paediatric Surveillance Unit - for each current study, and for previous months.

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Reporting instructions - January 2018

Conditions under surveillance:

  1. HIV infection and perinatal HIV exposure
  2. Progressive intellectual and neurological deterioration
  3. Congenital rubella
  4. Congenital Zika syndrome
  5. Life threatening bronchopulmonary dysplasia
  6. Juvenile-onset Systemic Lupus Erythematosus (JSLE)
  7. Listeria infection <90 days
  8. Severe Microcephaly

Important notice: Please inform the BPSU office of retirements or circumstances that will affect your ability to return the orange card. Complete the report card by ticking "nothing to report" or indicating the number of cases of the listed conditions seen in the month specified.

Download January 2018 reporting instructions (PDF, 67KB)

1. HIV infection and perinatal HIV exposure

Case Definition: Any child less than 16 years of age who has HIV infection. Also any child born to a woman known to be HIV infected at the time of that child’s birth regardless of the child's infection status.

Reporting Instructions: Please report any child not previously reported to the BPSU who meets the case definition.

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2. Progressive intellectual and neurological deterioration

Case Definition: Any child under 16 years of age at onset of symptoms who fulfils all of the following three criteria:
  • Progressive deterioration for more than three months with
  • Loss of already attained intellectual/developmental abilities and
  • Development of abnormal neurological signs.

Excluding: Static intellectual loss e.g. after encephalitis, head injury or near drowning.

Including: Children who meet the case definition even if specific neurological diagnoses have been made.      

  • Metabolic disorders leading to neurological deterioration.
  • Seizure disorders if associated with progressive deterioration.
  • Children that have been diagnosed as having neurodegenerative conditions but not yet developed symptoms

Reporting restricted to: Cases seen in the last month but including those whose conditions began earlier (i.e. including `old cases’ of children in follow-up if seen in that month).

Reporting Instructions: Please report any child seen in the last month who meets the case definition, including those who have already been given a specific diagnosis.

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3. Congenital rubella

Case Definition:  Any infant (live or still born) or child up to 16 years of age who, in the opinion of the notifying paediatrician, has suspected or confirmed congenital rubella with or without defects, based on history, clinical and/or laboratory findings.  Please include “imported cases”, including children born in the British Isles where the maternal infection occurred abroad, AND children who were born abroad.

Reporting Instructions: Please report any infant (live or still born) or child seen by you for the first time in the last month who meets the case definition, regardless of country of birth

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4. Congenital Zika syndrome

Case definition: All infants ≤ 12 months of age with a head circumference > 2 standard deviations below the mean for gestational age and sex (i.e. below the 2nd centile) or any neurological abnormality requiring investigation whose mother has travelled to a country with active Zika transmission during pregnancy or in the three months prior  to  conception.

Exclusion criteria: Travel only to countries without reported Zika transmission (Please check on: http://ecdc.europa.eu/en/healthtopics/zika_virus_infection/zika-outbreak/Pages/Zikacountries-with-transmission.aspx)

Reporting instructions: Please report any cases of infant ≤ 12 months in the past month presenting with congenital Zika syndrome as defined by the case definition.

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5. Life threatening bronchopulmonary dysplasia

Case definition: Any infant initially delivered at <32 completed weeks of gestation, without associated significant (including cardiorespiratory) congenital abnormality, where at (or beyond) 38 weeks postmenstrual age the infant is receiving positive pressure support by any route (ventilation, nCPAP, BIPAP or humidified high flow nasal cannula with a flow more than 2lpm), or receiving pulmonary vasodilators without intercurrent illness to explain this need.

Reporting instructions: Please report any child seen in the last month who meets the case definition in the UK or the RoI.

6. Juvenile-onset Systemic Lupus Erythematosus (JSLE)

Case definition: Any child / young person aged up to 18 years of age who:

1. Has a new, consultant diagnosis of suspected JSLE AND
2. Fulfils 2 or more ACR criteria* AND / OR has lupus nephritis on biopsy AND
3. Has no alternative diagnosis for relevant disease features
 
* A copy of the ACR criteria can be viewed at http://www.rcpch.ac.uk/bpsu/lupus

Reporting instructions: Please report any child / young person aged up to 18 years of age who meets the case definition in the UK or the RoI.

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7. Listeria infection in infants <90 days

Case definition: In young infants <90 days a microbiologically confirmed listeria sepsis or meningitis, or  in babies < than 7 days old probable listeria sepsis or meningitis defined as Isolation or PCR confirmation of listeria from maternal cultures (Blood or CSF, placenta or genital tract) and/or isolation of listeria from surface swabs, meconium or nasogastric aspirate from baby and clinical signs of sepsis and treatment of the baby with at least 5 days of appropriate antibiotics, or clinical signs of meningitis and CSF pleocytosis (WCC ≥20 cells / mm3).

Reporting instructions: Please report any infant of 90 days of age or less with a clinical diagnosis of invasive listeria infection according to the treating clinician or with suspected listeria infection treated for at least 5 days with appropriate antibiotics in the UK and ROI.

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8. Severe Microcephaly

Case definition: Any live born infant up to and including 12 months of age who has a head circumference more than 3 standard deviations below the mean (<-3SD), adjusted for age-, sex- and gestation (using the UK-WHO growth chart standard or UK90 growth chart for babies under 2 weeks of age).

Excluding: infants with anencephaly, and/or similar neural tube defects, (where the standard measurement of occipito-frontal circumference is not appropriate).

Reporting instructions: Please report any live born child aged up to and including 12 months of age who:

  • has been diagnosed with microcephaly in the past month,

and/or noted to have a head circumference that is:

  • more than three standard deviations below the mean (<-3SD) for gestational age and sex, or below the <0.4th percentile for age and sex.

Use your standard growth chart.

If you are unsure whether the child meets the case definition, for example an infant has only had one abnormal head measurement, please report the child or contact the principal investigator.

Excluding:Please do not report babies with anencephaly.

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Previous month's reporting instructions

Reporting instructions - December 2017

Reporting instructions - November 2017

Reporting instructions - October 2017

Reporting instructions - September 2017

Reporting instructions - August 2017

Reporting instructions - July 2017

Reporting instructions - June 2017

Reporting instructions - May 2017

Reporting instructions - April 2017

Reporting instructions - March 2017

Reporting instructions - February 2017

Reporting instructions - January 2017

Reporting instructions - December 2016

Reporting instructions - November 2016

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