BPSU - Acute Pancreatitis in the UK and Ireland

Surveillance of acute pancreatitis concluded its surveillance period in April 2013 and is in the process of collecting and analysing data. The study team are hoping to understand the incidence, clinical presentation, clinical management and outcome of the condition.

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Lead investigator

Professor Julian Hamilton-Shield
Bristol Royal Hospital for Children
Upper Maudlin Street
Bristol
BS2 8AE

Project co-ordinator

Dr A Majbar
Level 6 UHBT Education Centre
Bristol Royal Hospital for Children
Upper Maudlin Street
Bristol
BS2 8AE

Email: A.A.Majbar@bristol.ac.uk

Overview

There are many causes for acute pancreatitis including: viral infections; trauma; gall-stones; congenital abnormalities in pancreatic anatomy (formation); inherited genetic conditions; alcohol misuse and iatrogenic drug side effects.

The treatment and management of children with pancreatitis is varied as the condition is quite rare in childhood and it is currently difficult to know what constitutes the best management strategy for this condition for any given child.

This study has been designed to examine the epidemiology, medical management, surgical treatments and complications of acute pancreatitis with the aim of improving understanding of the condition and how best to treat it.

The British Association of Paediatric Surgeons (BAPS) is supporting this study and will be included in the reporting process.

Case definition: Any infant or child up to the age of 15.

Presence of at least two of the following three criteria. Imaging evidence is not necessary for diagnosis of Acute Pancreatitis if the other two criteria are fulfilled:

1) Clinical evidence (symptoms): Abdominal pain compatible with acute pancreatitis.

2) Biochemical evidence (laboratory):

a) Serum amylase raised three times above the normal reference range for the local laboratory

and/or

b) Serum lipase raised three times above the normal reference range for the local laboratory

3) Imaging evidence (radiological): Signs of acute pancreatitis detected by changed in the imaging studies, like US, CT scan, MRI, MRCP etc.

Duration:  Start date April 2013 (13 months of surveillance with a further 12 months follow-up).

Funding: Bristol University
 
Ethical approval: NRES Committee – South West Central Bristol – (REC reference 11/SW/0132). Public Health England has approval under Section 251 of the NHS Act 2006 under reference  ECC 6- 02(FT12)/2012 to process confidential patient information for public health purposes (see The Health Service (Control of Patient Information) Regulations 2002). 

Further information