BPSU - Surveillance of All Kawasaki Disease (Incomplete and Complete)

Surveillance of complete and incomplete Kawasaki disease in UK and Irish children began in February 2014 and will continue for 13 months. The study team hope to learn about the incidence, clinical presentation, management and outcome of the condition.

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Lead investigator

Tulloh image.jpg

Dr Robert Tulloh
Dept of Paediatric Cardiology
University Hospitals of Bristol NHS Foundation Trust
Upper Maudlin Street
Bristol, BS2 8BJ

Email: robert.tulloh@UHBristol.nhs.uk


Kawasaki disease is the commonest cause of acquired heart disease in children in the UK and USA. The serious sequelae of Kawasaki disease make it important to diagnose this condition early in order to treat it effectively and therefore minimise complications and long term ill health within the Paediatric population.   The last BPSU survey of KD was in 1990 and since that time there has been increased awareness of the condition and treatment protocols. 
NOTE: this is now a new study taking in ALL cases of Kawasaki disease, incomplete (including atypical and partial) and complete forms. We no longer exclude streptococcal infection in the criteria.
Case definition: Any infant or child up to the age of 16 years presenting for the first time with Fever of 5 or more days duration plus 4 of the following (complete) or plus any 2 of the following and coronary artery changes (atypical) or plus 2 or 3 of the following (incomplete):
  1. Conjunctivitis - Bilateral, bulbar, non-suppurative
  2. 2. Lymphadenopathy - Cervical  > 1.5cm
  3. Rash - Widespread, polymorphous. Not vesicular. 
  4. Lips and mucosa - Red cracked lips, ‘strawberry tongue’, erythematous oral cavity  
  5. Changes of extremities - Erythema, oedema of palms and soles initially, then peeling of skin at later stage.   
Exclusion: None. (No longer are we excluding streptococcal infections)
Duration: February 2014 –February 2015 (13 months of surveillance).
Funding: Kawasakidisease parent support group – Web: www.kssg.org.uk Email: enquiries@kssg.org.uk

Ethical approval: This study has been approved by NRES Committee – South West – (REC reference 11/SW/0310) and has been granted Section 251 permission under reference: ECC 6-02 (FT11)/2012.

Further information