Toxic Shock Syndrome

Shazia Adalat.jpgTom Dawson photo 2.jpg

Lead investigators 

Dr Shazia Adalat 

Tel: 0207 1884586

Dr Tom Dawson


Paediatric Nephrology Department
Evelina Children’s Hospital
Guys & St. Thomas’ NHS Trust
Westminster Bridge Road


  • Toxic shock syndrome (TSS) is a rare toxin related disease with potentially fatal or catastrophic consequences. 
  • This aggressive disease is triggered by staphylococcal or streptococcal toxin release. Immune mediated superantigen responses to toxin result in sustained shock followed by multisystem illness. This may manifest as diarrhoea, thrombocytopenia, coagulopathy, renal failure, hepatic impairment, soft tissue necrosis or acute respiratory distress syndrome (ARDS).
  • There is little data on the incidence of TSS in children in the UK or indeed significant case series commenting on presentation or outcome.
  • This BPSU study will inform paediatricians about incidence and management of this potentially fatal condition

Duration: October 2008 – October 2009 (13 months)
Funding:  Sir Peter Tizard Bursary, BPSU.

Ethical approval: This study has been approved by the Lewisham MREC (Ref: 08/H0810/16) and has been granted PIAG Section 251 Support (Ref: PIAG/BPSU 5-07 (FT2)/2008).

Further Information