16 December 2019
Domperidone is no longer licensed for use in children younger than 12 years or those weighing less than 35 kg because of a lack of evidence for benefit.
Results from a placebo-controlled study in children younger than 12 years with acute gastroenteritis did not show any difference in efficacy at relieving nausea and vomiting compared with placebo. We recommend healthcare professionals consider alternative treatments to domperidone in children younger than 12 years of age who need relief of symptoms of nausea and vomiting.
We also remind healthcare professionals of the important precautions for use of domperidone introduced in 2014.