BPSU study - Complete and incomplete Kawasaki disease (KD)

Surveillance of complete and incomplete Kawasaki disease (KD) in British and Irish children concluded in February 2015. The study team hope to learn about the incidence, clinical presentation, management and outcome of the condition. The study group have yet to publish their findings.

A paper has now been published in Archives of Disease in Childhood. A link to the abstract can be found below.

Lead investigator

Dr Robert Tulloh
Dept of Paediatric Cardiology
University Hospitals of Bristol NHS Foundation Trust
Upper Maudlin Street
Bristol BS2 8BJ
Email: robert.tulloh@uhbristol.nhs.uk

About the study

Overview

Kawasaki disease is the most common cause of acquired heart disease in children in the UK and USA. The serious effects resulting from Kawasaki disease make it important to diagnose this condition early, in order to treat it effectively and therefore minimise complications and long term ill-health within the paediatric population. The last British Paediatric Surveillance Unit (BPSU) survey of kawasaki was in 1990 and since that time there has been increased awareness of the condition and treatment protocols.

You can download the protocol card, including references, below.

Publications

Published papers

Case definition

Any infant or child up to the age of 16 years presenting for the first time with fever of five or more days duration plus four of the following (complete) or plus any two of the following and coronary artery changes (atypical) or plus two or three of the following (incomplete):

  1. Conjunctivitis - Bilateral, bulbar, non-suppurative
  2. Lymphadenopathy - Cervical > 1.5cm
  3. Rash - Widespread, polymorphous. Not vesicular.
  4. Lips and mucosa - Red cracked lips, ‘strawberry tongue’, erythematous oral cavity
  5. Changes of extremities - Erythema, oedema of palms and soles initially, then peeling of skin at later stage.

Exclusion

None. (No longer are we excluding streptococcal infections).

Duration

February 2014 –February 2015 (13 months of surveillance).

Funding

Kawasaki Disease parent support group.

Approval

This study has been approved by NRES Committee – South West – (REC reference 11/SW/0310) and has been granted Section 251 permission under reference: ECC 6-02 (FT11)/2012.

Support group